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As advised we able a alternation of PSeD-U elastomers with altered concentrations of UPy groups (named as PSeD-Ux, breadth x agency the assertive equiv of UPy groups based on the abstract amounts of hydroxyl groups) (Supplementary Figs. 1 and 2). The added atomic weights of PSeD-U polymers compared with PSeD accepted the adeptness of these reactions (Supplementary Table 1). The structures of resultant polymers were accepted by NMR spectroscopy (Supplementary Fig. 3). The absolute UPy capacity in PSeD-U polymers were abutting to the abstract capacity apparent by comparing the about proton integrations of the pyrimidyl groups in UPy at δ 5.71 ppm and the methylene groups in sebacate at δ 2.27 ppm (Supplementary Table 1). The inductively accompanying claret (ICP) tests were performed to added affirm the absolute UPy absorption in the PSeD-U elastomers (Supplementary Table 2). The acknowledgment adeptness and polymer structures were added accepted by attenuated absolute reflectance Fourier adapted bittersweet (ATR-FTIR) (Supplementary Fig. 4). The PSeD-U polymers were thermally convalescent for agreed times to access assorted amalgam crosslinked elastomers (e.g., PSeD-U20-12h agency that 12-h convalescent PSeD-U20). The advanced bend X-ray diffraction (WXRD) patterns of these PSeD-U elastomers alone displayed a ample baggy diffraction aiguille at a 2θ of 21°, suggesting that they are all baggy at allowance temperature (Supplementary Fig. 5). To added analyze the amalgam crosslinked structures of our system, we performed the rheological tests of both PSeD and PSeD-U elastomers by barometer the accumulator and accident moduli at altered frequencies beneath connected low ache (0.5%) (Supplementary Fig. 6). The accumulator modulus (G′) of PSeD-12h and PSeD-U20-12h elastomers were college than their accident modulus (G″) beyond the abstinent abundance range, demonstrating their covalently crosslinked atomic structures37,38. The G′ of PSeD-12h elastomers remained about connected beyond the abundance ambit due to the abiding covalent crosslinked network. Compared with PSeD-12h elastomers, the PSeD-U20-12h elastomers showed a affable frequency-dependent trend partly acquired by the activating hydrogen bonds. However, the accumulator modulus of PSeD-U20-12h added boring with the abundance and was hardly college than that of PSeD-12h elastomers, which adumbrated the access of hydrogen bonds to the accumulator modulus was limited. Meanwhile, the G″ apparent a frequency-dependent trend for PSeD-U elastomers, advertence that the sacrificial hydrogen bonds accept a added apparent aftereffect on the G″34. With the abundance added to access the hydrogen bonds kinetics, the break of hydrogen bonds and alternation alleviation produced activity amusement and led to college G″ of PSeD-U20-12h than that of PSeD-12h elastomer. Based on the altered amalgam crosslinked structures, the PSeD-U elastomers showed soft, tough, and able automated performance. Aback absorbed assimilate animal skins, the ultrathin PSeD-U elastomers blur (70 µm) could sustain the amplitude and compression of accustomed animal motions and alike appearance a conformal adapter to arced bark and channelled surfaces (Fig. 1b). Such an ultrathin blur anatomy and bendable attributes acquiesce the PSeD-U elastomer to be continued and aeroembolism with the bark advisedly and reversibly, arch to the abiding adherence and conformability. The PSeD-U elastomers showed ample stretchability (Fig. 1c) and strong, boxy automated achievement agnate to animal bark (Fig. 1d). The above automated achievement acceptable the skin-like elastomers to be calmly bogus into ultrathin films, which were able to be handled afterwards tearing25.



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The automated backdrop of PSeD-U20 elastomers with altered covalent crosslink densities were advised by adjusting the abating times (Supplementary Fig. 7). The elastomers with altered covalent crosslinks densities were quantitatively accepted by their agnate abscess ratios in the N,N-Dimethylformamide (DMF) (Supplementary Table 3). In appearance of the mechanically biomimetic properties, the PSeD-U20-12h elastomers had the modulus (0.64 ± 0.10 MPa) abutting to the bark (0.42-0.75 MPa)39, and a about aerial toughness. Thus, the 12-h abating time was called for added test. The aftereffect of UPy groups on the automated backdrop of elastomers were again evaluated (Fig. 2a and Supplementary Fig. 8). Compared with PSeD-12h elastomers, the compactness backbone (0.73 ± 0.10 MPa) and best addendum (297 ± 16%) of PSeD-U10-12h added by 1.14 and 2.18 times, while befitting a agnate Young’s modulus. With the access of UPy groups (PSeD-U20-12h), the compactness backbone and best addendum added added to 2.42 ± 0.54 MPa and 509 ± 24% while announcement an about connected Young’s modulus of 0.64 ± 0.10 MPa (Fig. 2a). The courage (the breadth beneath strain–stress curves) of PSeD-U20-12h was bigger by added than 11 times compared with PSeD-12h elastomers and college than the added appear PGS-based elastomers (Supplementary Fig. 9), demonstrating the able activity amusement adequacy of hydrogen bonds in PSeD-U elastomers. It is account acquainted that sacrificial hydrogen bonds do not accord to the antecedent stiffness, as the Young’s moduli of these elastomers were all abreast 0.60 MPa. This abnormality is in accordance with the antecedent studies of “mechanically invisible” polymeric materials34, breadth the concrete sacrificial bonds in abstracts that did not accord to the antecedent acerbity but abundantly blown automated activity with an added addendum and stress. Presumably, in these elastomers, the Young’s modulus was mainly bent by the covalent crosslinking anatomy and polymer chains entanglements rather than the low absorption of hydrogen bonds, which bogus the hydrogen bonds “mechanically invisible” at antecedent deformation. According to this assumption, aback the hydrogen band absorption added to a assertive percentage, hydrogen bonds would accord to antecedent modulus as well. Accordingly, the PSeD-U30-12h elastomer showed a cogent college Young’s modulus (1.49 ± 0.24 MPa), acceptable due to the stronger hydrogen bonds induced by the UPy units and carbamate linkages in added UPy-HDI groups (Supplementary Fig. 10). These after-effects accepted our antecedent and adumbrated the about low absorption of hydrogen bonds beneath a assertive analytical bulk is the key point to accumulate the low modulus. The stress-relaxation abstracts at connected strains were performed to added affirm the role of hydrogen bonds in Young’s modulus. At baby ache (5%), the bead of the accent of PSeD-U10-12h and PSeD-U20-12h elastomers were actual limited, agnate to that of PSeD-12h elastomer (Fig. 2b). These after-effects were affirmation that the hydrogen bonds of these PSeD-U elastomers had bound aftereffect on the antecedent modulus. However, at ample ache (300%), the absolution of activated force of PSeD-U20-12h elastomers was abundant college than the one at baby strain, advertence the activity amusement resulted from the strain-dependence break of hydrogen bonds (Supplementary Fig. 11). Furthermore, the elastomeric networks were estimated appliance classical Neo-Hookean archetypal with the acceptance that the polymer chains of the elastomers were Gaussian chains and that the diminutive anamorphosis of the polymer chains of the elastomers was proportional to the arresting anamorphosis of the elastomer (Supplementary Fig. 12). The agnate modulus additionally adumbrated the addition of low absorption of hydrogen bonds would accept little aftereffect on the boilerplate atomic weight amid the crosslinking points20. To abstraction the apparent apparatus of automated behavior of PSeD-U elastomers, the stress–strain ambit was disconnected into three regions depending on the altered ranges of anamorphosis (Fig. 2c and Supplementary Fig. 13)19. At low ache (region i), and the sacrificial hydrogen bonds were “mechanically invisible,” the PSeD-U20-12h elastomers showed a modulus agnate to PSeD-12h elastomers. With the access of strain, the hydrogen bonds dissociated to blow automated energy. As a result, the agnate abruptness of strain–stress curves in arena ii become abate than arena i. At ample ache (region iii), the hydrogen band break acceptable saturated. The above addition of the attrition of the activated ache was the covalent crosslinked networks. Accordingly, the modulus of arena iii added rapidly compared with arena ii. This altered automated contour of nonlinear stress–strain behaviors with self-stiffening backdrop during addition of PSeD-U20-12h elastomer was agnate to that of animal skin16.

a Typical compactness stress–strain curves of PSeD-U-12h elastomers with altered densities of hydrogen band while about identical covalent crosslinking densities. b The accent alleviation curves of samples continued at 5% ache for 900 s. c Dependence of accent on the strain, the stress–strain ambit can be disconnected into three regions depending on the ranges of strain. d Circadian compactness tests with a ache of 30%. e The compactness stress–strain curves of loading-unloading cycles with 300% ache with altered cat-and-mouse time amid two afterwards loadings. f The allegory of breach activity of PSeD-12h and PSeD-U20-12h. The admit photograph is a alveolate PSeD-U20-12h case with a ache of 300%, assuming its aerial breach resistance. Calibration bar = 10 mm.



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The circadian compactness tests at altered strains were performed to added authenticate the above mechanism. The loading and auction curves of PSeD-U20-12h elastomers at low ache (30%) were superimposable and showed negligible hysteresis (Fig. 2d). It is account acquainted that the fast anamorphosis and accretion at low ache (10–50%) is a adorable and important acreage for acoustic and actuating applications, such as bogus muscles40, skin-like sensors41, and tissue–electronic interfaces42. With the access of strain, the circadian compactness curves were no best superimposable and hysteresis started to develop. This adumbrated that allotment of the activated automated activity during addition action was blown (Supplementary Fig. 14). The circadian compactness ambit at 300% ache of PSeD-U20-12h elastomers showed an accessible hysteresis loop, but absolutely recovered to the aboriginal ambit afterwards a about abbreviate cat-and-mouse time (∼45 min) (Fig. 2e). The accretion action showed an absorbing two-stage action due to the antagonism amid the contractile force of the adaptable covalent arrangement affairs adjoin acting hydrogen bonds (Supplementary Fig. 15). While the attrition force of hydrogen bonds was acceptable constant. The contractile force from covalent arrangement was proportional to the deformation. Larger anamorphosis led to stronger adaptable contraction, which calmly dissociated the adapted hydrogen bonds and resulted in faster recovery. Abate anamorphosis had about weaker adaptable contraction, which was decidedly hindered by adapted hydrogen bonds, consistent in slower recovery. The circadian compactness tests were performed to appraise the robustness of PSeD-U20-12h elastomers (Supplementary Fig. 16). The repeatable stress–strain ambit and courage approved the able-bodied accretion adeptness of PSeD-U elastomers.

Tear attrition is additionally one of the important appearance of skin, abnormally accouterment the aegis from alien attack43. Similarly, the breach attrition of elastomers acclimated in electronics is additionally important for the aegis of chip circuits for wearable electronics. However, the antecedent appear skin-inspired elastomers rarely advised it. Rivlin–Thomas authentic microburst tests were performed to appraise the breach activity of the PSeD-U20-12h elastomers (Fig. 2f and Supplementary Fig. 17). The PSeD-U20-12h elastomer with a cut cleft could be auspiciously continued to 3.5 times and showed a disturbing activity of T = 3670 ± 86.6 J/m2, bigger two times compared with PSeD-12h elastomers (1738 ± 125.0 J/m2), advertence the able activity amusement of hydrogen bonds. Furthermore, the breach activity of PSeD-U20-12h elastomers was commensurable with bark (up to 3600 J/m2)44 and about four times college than broadly acclimated electric elastomer PDMS (960 J/m2)45.

Biological properties, such as biodegradability and biocompatibility, are important characteristics for animal banknote and awful adapted for skin-like elastomers and wearable electronics8,46. However, few studies appear biodegradable and biocompatible skin-like elastomers. The in vitro enzymatic abasement of PSeD-U elastomers was evaluated in 0.1 M dulbecco’s phosphate-buffered acrid solutions and 2000 U/mL lipase at 37 °C (Fig. 3a). During the tests, all the samples maintained their aboriginal rectangle shapes and apparent a bit-by-bit abatement in dimension. Compared with PSeD-12h, PSeD-U10-12h, and PSeD-U20-12h abject abundant slower with a actual weight of 48.2% ± 2.9% and 56.9% ± 7.1% afterwards 8 h, respectively, which approved that the able hydrogen bonds amid UPy units slowed the abasement of PSeD-U elastomers. Agnate abnormality was empiric in the abasement analysis afterwards lipase (Supplementary Fig. 18). Added importantly, the compactness backbone of PSeD-U elastomers showed a linearly bit-by-bit abatement with time, advertence their acceptable adeptness to absorb automated candor during abasement (Fig. 3b and Supplementary Fig. 19).

a In vitro enzymatic abasement of PSeD and PSeD-U elastomers in lipase DPBS solutions (0.1 M) at 37 °C. b Compactness backbone of PSeD-U20-12h at a ache of 200% afterwards abasement for 0, 2, 4, 6, 8 h, assuming a bit-by-bit abatement of automated strength. c Images of NIH 3T3 fibroblasts in live/dead assays of TCPS, PLGA, PSeD, and PSeD-U20. A ample bulk of alive beef (green) and few asleep beef (red) at all surface, advertence the acceptable biocompatibility of PSeD-U (magnification = ×100; calibration bar = 100 μm). d The MTT appraisal of NIH 3T3 fibroblasts beef able on TCPS, PLGA, PSeD, and PSeD-U20 elastomers. There was no cogent aberration amid altered abstracts at the aforementioned time point. Statistical acceptation compared with antecedent time point was apparent as *p < 0.05 or **p < 0.01.

The cytocompatibility of PSeD-U polymers was evaluated by agriculture NIH 3T3 fibroblasts on PSeD-U20. The tissue ability polystyrenes (TCPS), blunt PSeD, and poly(lactic-co-glycolic acid) (PLGA) were acclimated as controls. Afterwards 48 h, live/dead assays acutely showed a ample cardinal of alive beef (green) and few asleep beef (red) at all apparent (Fig. 3c). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium boiler (MTT) appraisal was conducted to appraise the fibroblasts admeasurement on PSeD-U20 (Fig. 3d). The cardinal of metabolically alive fibroblasts on PSeD-U20 decidedly added with the time of ability and was not statistically altered from those on TCPS, PLGA, and PSeD at the aforementioned time points. All these abstracts appropriate that PSeD-U20 had a acceptable in vitro biocompatibility, which is a key point for biomedical applications.

Subcutaneous article in mice was performed to appraise the in vivo biocompatibility of PSeD-U20-12h elastomers appliance PLGA as the ascendancy (Supplementary Fig. 20). Afterwards the implantation, all mice were in acceptable action and no infections or abscesses were observed. The anatomy weights of mice kept about connected during the aeon of experiments, which adumbrated the article had no adverse aftereffect on the advance of mice (Supplementary Fig. 20a). The hematological analysis was performed to added ascertain anarchic acknowledgment (Supplementary Fig. 20b). The ethics of white claret corpuscle (WBC) absorption in PSeD-U20-12h elastomers and PLGA groups were all agnate during the beginning period. Afterwards 7 canicule of implantation, both showed a slight access compared with accustomed mice afterwards implantation. That was mainly attributable to the surgical anguish inflammation47. In the afterward retrieving time credibility (14 and 28 days), the bulk of WBC decreased to accustomed level. To added appraise the in vivo biocompatibility of the PSeD-U20-12h elastomers, the concise and abiding host responses to implants were advised via H&E staining (Supplementary Fig. 20c). It was begin that the elastomers were amidst by apart affiliation tissue, advertence the balmy inflammation. These after-effects approved that PSeD-U20-12h elastomers apparent commensurable in vivo biocompatibility with the frequently acclimated biomaterial PLGA. The implants were retrieved at altered time credibility afterwards article (Supplementary Fig. 21). Compared with PLGA, the sizes of PSeD-U20-12h elastomers showed accessible change with the access of article time, demonstrating the acceptable biodegradability of PSeD-U20-12h elastomers.

In contempo years, soft, and adjustable skin-like cyberbanking accessories accept admiring added and added attentions and become a atypical belvedere to board with bendable tissues for human–machine interaction, bloom monitoring, and medical therapies3,6,8,48. Several skin-like sensors (e-skins, e-tattoos, epidermal device) based on altered mechanisms, such as resistive, capacitive, piezoelectric, and triboelectric principles, accept been developed and activated to the animal automated sensing15. The abstracts with an adaptable modulus alignment from 10 kPa to a few hundred kPa and able-bodied animation (deform up to 15%) were developed to accommodated the automated claim of bark electronics. Based on the skin-like cyberbanking materials, the bark electronics were able to board the cartography of the bark and board strains during accustomed anatomy motion. To authenticate the appliance of PSeD-U elastomers for bio-integrated electronics, we bogus the piezocapacitive burden sensor based on a microstructured PSeD-U20-12h elastomer dielectric film. Schematic analogy declared the architecture assumption of the piezocapacitive burden sensor, which consists of a microstructured PSeD-U dielectric band amid the top and basal electrodes (Fig. 4a). Figure 4b shows the SEM angel of the microstructured apparent of the PSeD-U dielectric band with a array of about 100 µm, which were able by spin-coating PSeD-U20-12h elastomer assimilate a cone-shaped belly categorical silicon dent mold. The pyramids on the apparent of PSeD-U20-12h elastomer had a acme of 3.4 µm, a pyramid abject amplitude of 5 µm, and a agreement amid pyramids of 5 µm. These cone-shaped microstructures provided voids that acquiesce the PSeD-U20-12h dielectric band to elastically and reversibly batter in acknowledgment to activated pressure. Gold was called for the electrodes due to its biocompatibility49. A burden sensor with a admeasurement of 2 × 2 cm2 was acclimated to investigate the burden sensitivity. The acuteness (S) was authentic as the abruptness of the ambit in Fig. 4c (S = δ(ΔC/C0)/δP), breadth C and C0 were the capacitances with and afterwards activated pressure, and p was the activated pressure. The piezocapacitive sensor appliance the microstructured PSeD-U dielectric band showed two altered stages with altered compressive behaviors aloft an access in the burden input. The burden acuteness is 0.16 kPa−1 in a airy administration (p < 2 kPa) and 0.03 kPa−1 at college pressures (2 < p < 10 kPa). The low modulus of the PSeD-U20-12h elastomers and the capricious compressibility of the microscaled pyramids anatomy on the apparent of dielectric band were advised the key appearance for the acute pressure-sensing capability. It should be acclaimed that the burden acuteness could be added bigger by optimizing the ambit of microstructures. These burden sensors showed accelerated acknowledgment to the activated pressure, abnormally in the burden absolution stage. The acknowledgment time for the acknowledgment to the aboriginal baseline was in the millisecond ambit due to the accomplished animation of the microstructured PSeD-U dielectric band (Fig. 4d). The burden sensors apparent acceptable adherence and showed basal hysteresis beneath circadian compression analysis (Fig. 4e, f). The burden sensor produced capricious burden acknowledgment curves with stable, noise-free, and alternating achievement signals through circadian compression testing at assorted pressures or frequencies. This accomplished pressure-sensing achievement of the PSeD-U elastomer burden sensor would be actual advantageous for animal concrete burden sensing. A burden sensor was absorbed to the animal throat and the capacitances change during animal allege activities was recorded (Supplementary Fig. 22). Aback the actuality batten the byword of “DHU”, the about capacitance change curves apparent agnate and again appropriate peaks, which approved the able applications of burden sensors in human/machine interaction. Furthermore, to authenticate the applications for stretchable electronics, skin-like ache sensors were able by spraying argent nanowires on PSeD-U elastomer films (Supplementary Fig. 23). The analogously broadcast argent nanowires formed a conductive network, which showed a ache acute conductivity. Due to the skin-like benevolence and acceptable stretchability, the ache sensor was able of not alone addition to board the strains of animal motion but additionally deforming to board the cartography of the skin. As a result, the motion of wrist including angle and addition was able-bodied detected by the change of the attrition of the sensor actuality absorbed to the aback of a wrist.

a Schematic of the anatomy of the piezocapacitive burden sensor. b SEM images of the microstructured PSeD-U20-12h elastomer dielectric film. c Pressure–response ambit of the piezocapacitive burden sensor. d Acknowledgment times of the burden sensor with the burden of 0.84 kPa. The inset shows the acknowledgment time of the burden sensor to burden release. e Activating responses of the burden sensor at assorted pressures with a abundance of 0.08 Hz. f Activating responses of the burden sensor at assorted frequencies with a burden of 2.86 kPa.

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